Beilstein J. Org. Chem.2015,11, 763–772, doi:10.3762/bjoc.11.86
residues (His) are important for safe and efficient siRNA transfection, this study indicates that AAdPGs containing higher degrees of His display lower cytotoxicity and more efficient endosomal escape.
Keywords: arginine; dendritic polyglycerolamine; histidine; multivalentvector; siRNA delivery
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Graphical Abstract
Scheme 1:
Synthesis of multivalent arginine and histidine functionalized dPG-NH2 50%. The depicted dPG-NH2 re...